Humans have also developed resistance to diarrhea vaccines?

Vaccination is currently considered to be the most important method of reducing mortality. Unfortunately, some studies have shown that the two live vaccines Rotarix and RotaTeq available by the World Health Organization do not achieve the expected benefits in developing countries. The protective effect of vaccines in many African countries has been as low as 20 -

Release date: 2014-10-20

Recent studies have shown that acute diarrheal diseases cause almost one in five deaths in developing countries, the most common cause being diarrhea caused by rotavirus. Improving sanitation and hygiene can limit the spread of disease. Vaccination is currently considered to be the most important method of reducing mortality. Unfortunately, some studies have shown that the two live vaccines Rotarix and RotaTeq available by the World Health Organization do not achieve the expected benefits in developing countries. The protective effect of vaccines in many African countries has been as low as 20-50%.

A study by Professor Lennart Svensson's research team published in the journal Clinical Infectious Diseases shows that more than four in four children in Burkina Faso have developed resistance to the vaccine.

The researchers found that the child's small intestine could not express a specific sugar molecule, called the Lewis molecule. In the existing vaccine, it was found that the Lewis molecule could pass the rotavirus without being infected. It may be that the Lewis molecule may act as a receptor for the rotavirus to enter the intestine and infect the host cell. This means that these children are not immune to the vaccine they need.

These children with negative effects in Louis are rare in Europe and North America, but these children are 10 times more likely in many African countries than countries such as Europe and North America.

These results have received international attention, which will greatly affect the assessment of rotavirus vaccines in some developing countries. As a result, the components of the vaccine may be re-examined, which will make the reconstituted vaccine more suitable for people infected with rotavirus.

Source: Bio Valley

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