1. Effect on the central nervous system: Acanthopanax has effects on the excitability and inhibition of the central nervous system. A single administration shows a stimulatory effect on the central nervous system, and continuous administration shows a strong effect. Acanthopanax not only improves the excitement process, but also strengthens the inhibition process, so that the inhibition tends to be concentrated, the differentiation is more complete, and the process of inhibition of the cerebral cortex increases. Its excitatory principle differs from that of amphetamines. It not only has low toxicity, but also does not disturb normal sleep. Acanthopanax's excitement or inhibition of the nervous system is related to the functional state and dose size of the nervous system when administered.

Excitatory effects: In the rabbit's electroencephalogram showed that Acanthopanax extract can weaken the inhibitory effect of chloral hydrate, barbiturate and chlorpromazine, and the central nervous system has obvious ginseng-like excitatory effect. Acanthopanax extract can also shorten the anesthetic process of ether and increase the excitability of ether or chloral hydrate anesthesia.

Inhibitory effect: Acanthopanax extract has a sedative effect on the central nervous system. It can prolong the hexene anaesthesia time and reduce the excitability after hexene anaesthesia.

Anticonvulsant effect: In some experiments, injection of saturated sodium chloride for several minutes before the animal died will increase the extent of extensor contracture; if the animal is given anesthesia one hour before fixation, the spasticity of the poisoned mice obviously decrease.

2, anti-fatigue effect: Acanthopanax root extracts and Steroids have anti-fatigue effect. The role of earthworms is stronger than that of the extracts, and it is stronger than that of the ginseng extracts and the ginseng roots. Intraperitoneal injection of Acanthopanax alcohol extract aqueous solution 20g/kg, an average of 1/4 of the swimming time of mice. Acanthopanax senticosus bark aqueous extract 500mg/kg and its clove resin phenol-di-oBD- glucoside 50mg/kg can significantly prolong rat swimming time. The mouse climbing rope test was used to determine the physiological activity of Acanthopanax senticosus at different growth stages. It showed that: 1g of dried roots in May was 79SUA33/g (excitatory action unit), and the activity decreased significantly in July, and reached the maximum before falling leaves in August. The value is 116SUA33/g. Acanthopanax leaves also showed similar changes (SUA33: experimental animals compared to control animals, delayed 33% at the failure of a SUA33). The extracts of Acanthopanax senticosus root and leaf can increase the activity energy of rats by 25% and 70%, respectively.

3. Anti-cancer effects: The extracts and total saponins of Acanthopanax senticosus have inhibitory effects on animal experimental xenografts, drug-induced tumors, cancer metastasis, and spontaneous mouse leukemia, and can also reduce anticancer drugs. toxicity. Rats and mice were inoculated with sarcoma 180 and sarcoma 256 tumors. Acanthopanax had a weaker inhibitory effect on the growth of sarcoma (4-28%). Acanthopanax extract can reduce the positive rate of Ehrlich ascites carcinoma transplanted in mice and reduce the lesions of cancer, and increase the effect of thiotepa on transplantation and development of Ehrlich ascites carcinoma. It does not change the positive rate of transplants of WACKER ascites sarcoma in rats, but it can reduce the lesions on the lungs. The mice were able to inoculate LID-1 and some other cancers with a reduced positive rate of transplantation, which can inhibit urethane-induced lung adenomas, reduce thyroid cancer caused by 6-MTU, and mouse myelogenous leukemia caused by sputum. Reduce the formation of spontaneous breast cancer and spontaneous leukemia in mice. After taking cyclophosphamide mice, taking Acanthopanax extract can improve the animals' survival time and survival rate. However, when taken together with cyclophosphamide in mice inoculated with sarcoma 180, Acanthopanax had no effect on the toxicity and anticancer effect of cyclophosphamide. Acanthopanax can also inhibit the proliferation of mouse SSK sarcoma and rat wach tumor. Reduce the blood-borne diffusion of hydrocortisone in mice after infusing Ehrlich ascites carcinoma. It can reduce the sensitivity of rat's Wacker's tumor and mouse sarcoma 180 to the toxic effects of cyclophosphamide and ethyl palmitodol. It can increase the median lethal dose of ethyl ethyl pentobarbital from 30 mg/kg to 46 mg/kg in mice with leukemia and can reduce the chronic poisoning symptoms caused by ethyl barbital and cyclophosphamide in experimental animals. Such as animal weight, thymus, adrenal gland weight and white blood cells and eosinophils, etc. have improved.

4, to adapt to the role of the original:

Acanthopanax can increase the body's non-specific resistance. Acanthopanax has a variety of harmful stimulatory factors, such as physical (cold, burning, overweight or weightlessness, excessive or compulsive immobility, centrifugation and radiation), and chemical ( The adverse effects of various chemical substances and organisms can increase the body's resistance. Acanthopanax can increase the ability of animals to resist radiation and have an anti-radiation effect on an acute X-ray or multiple chronic irradiations. Such as long-term irradiation (total dose 1620-7000r), Acanthopanax can extend the life of rats twice, and can improve the blood phase. Use with antibiotics can extend the life of rats irradiated for 60 days (total dose of 3000r). It protects red blood cells from radiation-like substances and can be used as a preventive and therapeutic agent for radiation damage. Acanthopanax Injection promotes 60Co-ray irradiation with a total dose of 4GY, resulting in the restoration of cellular structure of the mice following radiation injury of the hematopoietic system. Acanthopanax can antagonize the immunosuppressive effect of Robulus toxin C. There is a special antiviral immunity to tick-borne encephalitis. Acanthopanax can also reduce the number of deaths caused by the injection of digoxigenin in frogs and increase the detoxification ability of tricresyl phosphate and strychnine. Acanthopanax extract can increase the defensive ability of capillaries under low pressure, and reduce the incidence frequency of human body due to cold and hemoglobin content in blood. Acanthopanax sinensis alcohol extract, volatile oil, and total flavonoids of Acanthopanax have anti-hypoxia effect. A small amount of Acanthopanax root extract has a good influence on the metabolism and labor ability of the main system of high-temperature workers. Larger doses increase body temperature, perspiration, vital capacity, and exhaled carbon dioxide, increase oxygen consumption, and cortisol and male hormones in the adrenal cortex can relatively and absolutely rise. And can improve the body's adaptability to temperature changes (high temperature, freezing). Daily treatment of Acanthopanax extract 1ml/kg can increase the hen's egg production rate by 2.2 times.

Acanthopanax can regulate the pathological process, normalizing it can make the increase and decrease of red blood cells and white blood cells caused by chemical factors and biological factors return to normal. For example, the increase of red blood cells caused by cobalt nitrate and the reduction of red blood cells caused by quinones can restore normal blood. In the anesthetized cat experiment, Acanthopanax made the reduced blood pressure return to normal soon. Acanthopanax has antihypertensive effect. Acanthopanax can regulate endocrine dysfunction. Not only can prevent adrenal hyperplasia caused by adrenocorticotropic hormone, but also can reduce atrophy caused by cortisone. Can prevent thyroid hormone caused by thyroid hypertrophy, but also prevent methylthiouracil-induced thyroid atrophy. It is possible to lower the blood sugar level of food-related and adrenal hyperglycemia to normal, and it is also possible to increase the blood sugar level due to insulin-induced hypoglycemia. It can reduce the urine glucose in rats caused by alloxan-induced diabetes and prevent weight loss in rats, and has a blocking effect on the development of this diabetes. The corresponding endocrine weight changes can be prevented without affecting their catabolism. Acanthopanax can change the pathological process of the body's stress response during the alert period, prevent adrenal hyperplasia during this process, reduce cholesterol levels, shrink thymus and reduce gastric bleeding. The anti-alert period was the strongest with Acanthopanax senticosus E, Acanthopanax senticosus B1 was weaker, and Acanthopanax senticosus C had no effect. Acanthopanax can also produce a stress-resistance period. In addition to adrenal hypertrophy, cholesterol levels, spleen, and animal appearance were normal in rats during this period, and weight increased even faster than rats without swimming. In the exhaustion phase of the stress response, Acanthopanax can prevent the adrenal glands from shrinking, cholesterol levels decrease, and the weight of the thymus, spleen, liver, kidney, and heart decreases.

5. Anti-aging effects: After 2 months of feeding of Acanthopanax on 22-month-old rats, the red blood cell lipid peroxide was reduced by 17.75, Na+, and K+-ATPase activity was increased by 17.42%, suggesting a certain anti-aging effect.

6, the role of the cardiovascular system: anesthetized cats subcutaneous or intravenous injection of Acanthopanax extract can expand the brain blood vessels to improve blood supply to the brain. Acanthopanax can only see this effect at high doses. In addition, immediate administration (1 mg/(kg.day) of subcutaneous) of ligation of acute anemia in canines caused by carotid or cerebral arteries for 2 consecutive weeks alleviates the anemia, reduced blood pressure, and decreased hemoglobin caused by the above-mentioned causes. , the number of red blood cells, and electrocardiograms to improve the accompanying disease and compensatory anaemia. Ethanol extracts of Acanthopanax senticosus extract and its base leaves have a strong inhibitory effect on platelet aggregation. Acanthopanax extract also has an anti-arrhythmic effect, which increases the normal sinus rhythm time and significantly reduces the abnormal action potential. Acanthopanax extract can attenuate myocardial ischemic tissue damage, promote surface cell regeneration and myocardial infarction recovery.

7, antibacterial and anti-inflammatory effects: Acanthopanax on the adrenalectomy mice, in the summer, autumn and winter can reduce the thermal inflammatory edema, a slight anti-inflammatory effect in the spring. Rats with adrenalectomy can prevent the development of formaldehyde-induced joint inflammation in winter and spring. Can reduce the inflammation caused by saline and 15% protein solution. The first hour after injection of Acanthopanax extract from mice and rabbits infected with Listeria spp. reduced the animal's resistance to infection and subsequently significantly increased the resistance to infection, so it was thought to increase. The body's ability to enterobacteriaceae.

8. Effect on the endocrine system: There was no significant increase in epinephrine and blood cortisone hormone levels in rats given 15 minutes of quiescence and swimming. However, after 5 hours of swimming, the cortisone content was significantly increased. It has been reported that there is no significant change in the internal tissues of the adrenal gland after administration, but it has a direct and significant effect on the adrenal chromaffin tissue. Acanthopanax root extract and Acanthopanax senticosus have gonadotrophic effects. Male pups taking root extracts and total saponins isolated from leaves, or Acanthopanax B, B1 and E, both increased body weight and seminal vesicle and prostate weight and RNA content. Scorpion in the castration of male animals to prevent the atrophy of the seminal vesicle and prostate, female mice have a significant role in promoting female sex hormones, and promote precocious puberty and weight gain. After taking Acanthopanax extract, the egg production of the hen can be increased by 20.4%, the weight of the egg is increased by 24%, and the total nitrogen and protein in the fallopian tube are increased. The hen's egg hatched chick raises nitrogen and protein. Metabolism. The preparation of Acanthopanax can prevent sexual function caused by oxidized sunflower oil in rabbits, reduce the concentration and activity of sperm, and reduce the spontaneous abortion and death of female rabbits. Preventing hairless and perioral necrosis and liver and heart pathological changes caused by oxidized fat, vitamin E rarely has this effect.

9. Immunoenhancement: Acanthopanax senticosus polysaccharides (PES.) and its quinone B (purple eucalyptus), D and E (in both configurations of syringa resin phenolphthalein) can significantly increase the production of interferon-inducing cells. The ability to induce the S801 and S7811 leukemia cell lines was the best in PES (pure), followed by PES and ç”™B, D, and E. Opthas sinensis (50g/kg) has a protective effect on subcutaneous injection of cyclophosphamide-induced leukopenia, and it also has a significant preventive effect on benzene-induced leukopenia in mice and rabbits. Intraperitoneal injection of Acanthopanax Injection can inhibit leukopenia caused by cyclophosphamide. Acanthopanax Polysaccharides have a good effect on the reconstitution of B cells, and can reduce the leukopenia caused by cyclophosphamide, significantly enhance the hemolytic plaque assay of IgM and IgG secreted by mice spleen, and delay the induction of bovine serum albumin by mice. Hair type hypersensitivity. Acanthopanax can increase the phagocytic ability of the reticuloendothelial system and the phagocytic ability of macrophages in the peritoneal cavity, increasing the percentage of rosettes by 1.2-1.8 times. Acanthopanax senticosus polysaccharide can significantly increase the activity of CTL-killing target cells and promote the secretion of interleukin-2 by ConA-stimulated mouse spleen cells.

10. Other effects: Acanthopanax can increase the plasma concentration of eosinophils, a-globulin, the number of red blood cells, and the alkaline reserve in blood. Acanthopanax senticosus polysaccharides can significantly improve the liver poisoning caused by CCl4 and sulfamide acetamide, and can promote the body's ability to resist infection, have a certain resistance to tuberculosis infection, and anti-diuretic effect.

Function: Modern medical research proves that the role of Acanthopanax is basically the same as that of ginseng, with the ability to regulate the disorder of the body.

Acanthopanax

To make it normal to function. It has good anti-fatigue effect and is more significant than ginseng, and can significantly improve the ability to withstand hypoxia. Buzhong, Yijing, strong will, rheumatism, Zhuang bones, blood circulation, diuretic and other functions. Jiufu "light and hardworking". Acanthopanax contains the noteworthy ingredient -- Acanthopanax quinquefolium -- that stimulates mental and physical activity. Numerous scientific publications on Acanthopanax have demonstrated its anti-fatigue effect, enhanced stamina and ability, increased alertness and learning ability. Many uses have been confirmed in human experiments. Acanthopanax is a popular self-medication drug for people who recover from illness, suffer from excessive stress or stress, work excessively, who suffer from chronic weakness, and who are in need of physical and mental performance peaks. A considerable number of reports indicate that it has the ability to support the immune system, restore abnormally low blood pressure, improve the circulatory system, normalize disorders of glucose and lipid metabolism, and anabolic effects of liver, testis, bone density, and other vital organs.

1. Prevent stress from diseases

Acanthopanax contains Acanthopanax, which has a good effect on the adrenal glands. This tiny gland is located on the upper part of the kidney and secretes hormones that are resistant to fatigue. Taking Acanthopanax is considered to advance the body's physiological stress from heat exposure to overwork. And enhance the ability to resist disease. And the overall energy level of the human body.

2. Resist fatigue and restore energy

Acanthopanax showed increased acuity and physical endurance, but no efficacy was reduced with caffeine-containing products. Studies have shown that Acanthopanax can improve the use of oxygen in exercise muscles. This means that the body can maintain longer aerobic exercise and recover from exercise fatigue faster. A preliminary study by the Soviet Union shows that it may be very effective for this purpose.

Acanthopanax Root

3. Stimulate immunity

Acanthopanax extract has been shown to stimulate cellular immunity. Studies have found that it can stimulate the production of T-cells, especially helper cells. Therefore, Acanthopanax is used for a variety of immune-related diseases. German scientists have discovered that this herb may be of great help in the early stages of the treatment of AIDS. The study found that it can slow the spread of the virus by the cooperative action of an ascending number of helper cells and cytotoxic T cells.

Indications: cold dampness, bones and urgency, low back pain, impotence, weak beriberi, sores, swollen drugs, bruises. Qi and spleen, kidney and nerves. For spleen and kidney Yang deficiency, physical weakness, loss of appetite, waist and knee pain, insomnia and more dreams are particularly effective.

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