Release date: 2007-11-27 Britain finds out why the fetus is not attacked by the maternal immune system
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According to the British "New Scientist" magazine, British scientists have discovered why pregnant women's immune system does not attack the fetus and placenta. Since both the fetus and the placenta contain genetic material from the father, it is always a mystery as to what causes the fetus and placenta to escape the immune system of the pregnant woman.
A team led by Philip Laurie of the University of Reading in the United Kingdom found that the placenta can produce a hormone that is not yet known to humans by analyzing the placental tissue of humans and mice. The hormone and certain parasites are immune to immune system attacks. The released molecules are the same. The main reason why this placental hormone has not been discovered is that it is almost identical to the neurotransmitter used by the brain and nervous system to transmit signals, but with the addition of a molecule called choline phosphate, which makes it functional. A complete change has taken place. The researchers found that choline phosphate can be attached to neurokinin B and a precursor called hemokinin neurotransmitter.
Laurie believes that the main function of choline phosphate is to prevent the fetus and placenta from attacking the immune system. Since previous studies have shown that high levels of neurokinin B mean fetal malnutrition, releasing this hormone may also help the hungry fetus to gain more blood and nutrients. In addition, he believes that this placental hormone is also a factor that causes pregnancy-induced hypertension syndrome. Therefore, he hopes that the discovery of this placental hormone can open up new avenues for the treatment of habitual abortion, pregnancy-induced hypertension and rheumatoid arthritis.
However, some researchers have said that the study on the function of choline phosphate is not sufficient, and a lot of intensive research work is needed to determine the function of choline phosphate. ——Midi Medical Network
Britain finds out why the fetus is not attacked by the maternal immune system