1, the way of suppository drug absorption After the anus is administered with a suppository, the absorption of the drug in the rectum is mainly through the following routes: 1 drug through the superior rectal vein → portal vein → liver → large circulation. 2 drugs through the lower rectal vein and anal vein → internal iliac vein → lower venous vein → large circulation. 3 drugs are absorbed through the rectal lymphatic system. After vaginal suppository administration, since the blood vessels near the vagina are almost always connected to the large circulation, the absorption of the drug does not pass through the liver, and the absorption speed is faster. 2. Factors affecting drug absorption in suppositories There are mainly the following aspects: 1 physiological factors. The depth of suppository stuffed into the rectum affects the absorption of the drug. When the suppository is inserted 2cm away from the anus, the absorption of 50%-70% of the total dose can be passed through the portal system; When entering the anal mouth 6cm, most of the drug absorption should enter the portal system, and the drug is susceptible to the first action of the liver. 2 drug factors 3 matrix factors Hunan Zhongcheng Pharmaceutical Machinery Factory has a wide variety of products, suitable for use in pharmacies, clinics, pharmaceutical factories, hospitals, quality assurance, not satisfied with seven days return, one year warranty, lifetime maintenance, welcome new and old friends to log in to our company: Or directly dial the pharmaceutical technology department to play: Consulting, our factory will provide you with more professional services!
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Suppository drug absorption