Release date: 2009-08-21

Why do some people have high blood pressure and high blood pressure every day? Some people get diabetes at a young age? Why do some people smoke without lung disease for a lifetime, and some people do not have long-term smoke but have lung cancer early? Obviously, this It is because each person has a different genetic predisposition. Some people are prone to this disease, and some people are susceptible to that disease.
So, which disease are you susceptible to? Which diseases have a clear genetic predisposition? Let us, under the guidance of experts, learn to draw a “family disease spectrum” and develop a personalized family health plan based on the genealogy of the disease.
The disease can also be born with a family of "cancer curses"
The Bradfield family was originally an ordinary American family, but since the family's old grandmother, G. Bradfield, died of stomach cancer in 1960, the shadow of death has shrouded her descendants.
It turns out that since the old wife Gore died of stomach cancer, many members of this family have died of the same disease. Gore has seven children, six of whom died of cancer in their 40s and 50s. Among the 18 grandchildren (female) and grandsons (female) of the Bradfield family, David Allen died of this family genetic disease in 2003. Her family is like a "stomach curse", a total of 10 people died of stomach cancer or suspected stomach cancer.
Shortly thereafter, the remaining 17 people in the family underwent genetic testing, and 11 of them carried a mutant gene of a family-derived gastric cancer. According to researchers, the offspring carrying this mutant gene will have a 70% chance of developing stomach cancer. As a last resort, the 11 cousins ​​of the Bradfield family chose to completely remove the stomach when they were not already ill.
In fact, the phenomenon of family aggregation of cancer has not only occurred in foreign countries, but in China, such things are not uncommon. For example, some time ago, the media reported that three of the four brothers of Xiong’s Xi’an decided to work in Guangzhou, and the second son Xiong Shuigen left. In June last year, Xiong Shuigen went to the hospital for examination because of illness, and the result was colorectal cancer. The three brothers rushed back overnight. When I learned about the condition of the second child, the three of them felt awkward. This symptom also has wow. The results of the examination were shocking. Except for the third inflammation, the oldest and the fourth had colorectal cancer.
Coincidentally, Ms. Jin of Harbin was found to have lymphoma in her neck. Her second sister found herself in a nursing process and seemed to have a lump. After examination, she also got the disease. Later, the four sisters and niece in Korea were actually Malignant lymphoma was also detected. Hong Kong singer Anita Mui, her sister died in 2000 due to the same disease before her death of cervical cancer in 2004.
Focus on the genetic predisposition of disease
These "cancer families" are certainly some examples of "extreme". Many diseases are only genetically "prone" and will not be inherited 100%. However, it is an indisputable fact that many diseases have family heredity, whether it is from the common news or scientific research.
In other words, in the face of disease, not everyone is equal. Everyone's susceptibility to different diseases and tolerance to unhealthy lifestyles are different. Just like everyone is born with the difference between high and low fat, each person is different from the "affinity" of different diseases. For example, some people who have not smoked for the rest of their lives have lung cancer, and some people have never had lung cancer for the rest of their lives. This has caused some smokers to “have a good chance” and think that smoking may be fine. In fact, this is the family genetic susceptibility at work. In fact, those with a good genetic background in the family must have some cells changed after long-term smoking, but the repair genes in his body can quickly repair these damaged cells to avoid cancer; and some immune functions are poor. The sensational group is likely to suffer from lung cancer due to adverse stimuli such as smoking.
Recognizing this, we can make targeted prevention by tracking the illness of other members of the family and knowing what is susceptible to it. For example, if you have multiple relatives in your family who have diabetes, your chances of developing diabetes are much greater than those of the average person. Pay special attention to the monitoring and prevention of diabetes.
6 major diseases are genetically related
Many diseases have obvious genetic predispositions, and some people are more likely to suffer from certain diseases than others. So, what are the common diseases that have a genetic predisposition? If you belong to the high-risk group of these diseases, how should you plan ahead and block it from continuing on your own?
1. Hypertension: genetic risk:
Scientists have succeeded in developing a "hereditary spontaneous hypertension" mouse. This kind of mouse will pass on the genes of hypertension from generation to generation, and their offspring will have high blood pressure 100%, which is the most typical example of hypertension and genetics.
At present, most scholars believe that hypertension is a polygenic hereditary disease. Through the family survey of hypertensive patients, it is found that parents with high blood pressure have a high risk of high blood pressure of 45% in their children; those with high blood pressure in their parents have a 28% chance of having high blood pressure; The probability of children suffering from high blood pressure is only 3%.
Principle of prevention
1. Persist in monitoring blood pressure, at least once a year under normal conditions.
2. Limit salt and potassium. Gradually control the daily intake of salt to 5 grams, while eating more potassium-rich fruits and vegetables (such as bananas, walnuts, lotus seeds, alfalfa, leeks, spinach, etc.).
3. Prevent overweight and obesity.
4. Smoking cessation and alcohol restriction.
2. Diabetes: Genetic risk:
Diabetes has a clear genetic predisposition (especially the most common type 2 diabetes in the clinic). Family studies have found that people with a positive family history of diabetes have a significantly higher prevalence of diabetes than those with a negative family history. Parents have diabetes, and their children have 15 to 20 times more chances of developing diabetes than ordinary people.
Principle of prevention
The “external causes” of induced diabetes include excessive caloric intake, decreased activity, obesity, smoking, and excessive psychological stress. Conversely, avoiding these factors can prevent diabetes. In terms of diet, we should make a reasonable mix of food, meat, eggs, vegetables, and fruits, and pay attention to the balance between intake and consumption. Regular weight measurement, if the weight is increased, the calorie must be overdose, then you should review your diet and increase exercise.
3. Dyslipidemia: genetic risk:
There are many reasons for abnormal lipid metabolism, one of which is genetic factors. With the development of medical science, it has been found that a considerable number of patients with dyslipidemia have one or more genetic defects. The dyslipidemia caused by genetic defects has family familiality and obvious genetic predisposition. It is clinically known as familial dyslipidemia.
Principle of prevention
The most important thing is to emphasize "to open your legs and keep your mouth shut." On the one hand, we should properly limit the diet, but the food should be as rich as possible. Choose low-fat foods (vegetable oil, yogurt), increase vitamins, cellulose (fruit, vegetables, bread and cereals) to control weight. At the same time, strengthen the exercise so that the calories are consumed so that the fat does not accumulate in the body.
4. Breast cancer: genetic risk:
Breast cancer has a distinct family genetic predisposition. Epidemiological investigations have found that 5% to 10% of breast cancers are familial. If a close relative has breast cancer, the risk of illness increases by 1.5 to 3 times; if two close relatives have breast cancer, the prevalence will increase by 7 times. The younger the onset of the disease, the greater the risk of breast cancer among relatives.
Principle of prevention
Those with a family history of breast cancer should pay special attention to self-examination to discover the clues of breast cancer and early treatment. Breast mass is the most common sign of breast cancer. This mass is different from the breast hyperplasia mass. It is often single, irregular in shape, hard in texture, poor in activity, mostly painless, and has no obvious relationship with menstrual cycle. In addition, if you find nipple eczema, discharge, shrinkage, you should also pay attention to the hospital for further examination.
5. Gastric cancer: genetic risk:
Patients with gastric cancer have significant family aggregation. The survey found that first-degree relatives of gastric cancer patients (ie parents and siblings) were three times more likely to have gastric cancer than the average population. More famous, such as the Napoleon family, his grandfather, father and three sisters died of gastric cancer, and the entire family, including himself, had 7 people suffering from stomach cancer.
Principle of prevention
Risk factors for gastric cancer include lack of physical exercise, mental depression, smoking, eating smoked food, eating heavy salt diet, excessive intake of meat, Helicobacter pylori infection, and gastric ulcer. The fungi and fresh fruits are protective factors for gastric cancer. It is worth noting that the family aggregation of gastric cancer may be related to the common infection of Helicobacter pylori. Those with a family history of gastric cancer should go to the hospital to monitor the presence or absence of the bacterial infection, and then treat it promptly.
6. Colorectal cancer: genetic risk:
Colorectal cancer caused by family inheritance accounts for 10% to 15% of the total number of colorectal cancer cases. People with colorectal cancer in their relatives are three to four times more likely to develop the disease than the average person. If two or more close relatives (parents or siblings) in the family have colorectal cancer, they are at high risk for colorectal cancer. . ——Midi Medical Network

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