Tablet development

     

  Tablets were developed on the basis of the use of pills . It was used in the 1840s. By the end of the 19th century, with the emergence and continuous improvement of tableting machinery, the production and application of tablets have developed rapidly. In the past ten years, there have been great developments in tablet production technology and mechanical equipment, such as boiling granulation, full powder direct compression, semi-film coating, new auxiliary materials, new processes and production linkage. The research and production of traditional Chinese medicine tablets began only in the 1950s. With the comprehensive research on the chemistry, pharmacology, preparation and clinical aspects of traditional Chinese medicine, the variety and quantity of traditional Chinese medicine tablets have been increasing, the technology has been improved, and the quality of tablets has gradually improved. improve. In addition to general compressed tablets and sugar-coated tablets, traditional Chinese medicine tablets include microcapsule tablets, buccal tablets, external tablets and effervescent tablets. In the tablet production process, we gradually explored a set of process conditions suitable for the production of traditional Chinese medicine tablets, such as the preparation of tablets containing fatty oil and volatile oil, how to improve the hardness of Chinese medicine tablets, improve the disintegration degree, tablet coating Gradually accumulate experience, so that the quality continues to improve. In addition, research on the dissolution rate and bioavailability of drugs in traditional Chinese medicine tablets has been gradually carried out. In short, the tablet has become a variety, large output, wide application, convenient use and storage, and one of the quality stable dosage forms. Tablets account for more than 1/3 of the preparations in the pharmacopoeia of China and many other countries. It can be seen that the application is wide.

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