99% Purity Pharmaceutical Inosine For Anti-HIV CAS 58-63-9
Quick Detail:
Product Name                       Â
Inosine
Synonym
Atorel;beta-D-Ribofuranoside, hypoxanthine-9;
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CAS NO
58-63-9
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MF
C10H12N4O5
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MW
268.23
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EINECS
200-390-4
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Purity
99%
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Appearance
White Powder
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Melting Point
222-226 °C (dec.)(lit.)
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Density
1.3846
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Usage
Used as a coenzyme drugs regulate immune function class
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Description:
Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond. Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs. Wobble base pairs for inosine and guanine
Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism. Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of inosine monophosphate dehydrogenase. It is used in the treatment of a variety of autoimmune diseases including granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting from inosine monophosphate dehydrogenase (IMD) inhibition.
Usage:
1.Inosine improves cell viability in cultured neocortical neurons
2.Brain inosine levels increased transiently after oral administration of inosine
3.Inosine enhances cell proliferation and transcription of BDNF in the hippocampus
4.Inosine prevents depression-like behavior in chronically stressed mice
5.Inosine prevents depression-like behavior in chronic social defeat mice
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99% Purity Pharmaceutical Inosine for Anti-HIV CAS 58-63-9