Mental illnesses such as autism, depression, epilepsy, and Parkinson are now plaguing many people. The data shows that there are about 60 million people with epilepsy worldwide, of which about 10 million are in China. However, the scientific community is not fully aware of the mechanisms underlying these diseases. On the 27th, Wang Liping, Lu Yi, Wei Pengfei and other scientific research personnel of the "Optogenetic Technology R&D and Neural Loop Analysis" research projects made breakthroughs in this area, and won the first prize of the provincial natural sciences.

Wang Liping, director of the Institute of Brain Cognition and Brain Diseases of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, told reporters that there are many kinds of cells in the human brain, just like a sports field that houses 100,000 people of various kinds, and its structural mechanism is very complicated. Wang Liping said: "Our team rooted in Shenzhen this decade, is to concentrate on one thing - trace the source of different brain cells of the brain, establish a platform for optogenetics research and development and resource sharing. We use animal models such as Parkinson's disease as Research subjects, looking for specific pathogenesis, to accurately identify and intervene in the target of the diseased cell.” He pointed to a blue map like a starry sky outside the corridor, saying: “The brain is like a 'black box'. We use The method of genetic engineering enables specific nerve cells to express light-sensitive channels. When the blue light is directed at that point, the function of various cells can be understood from the reaction performance of the test object, and the brain function map can be drawn. Animal experiments have found that the perceptions and actions of eating, courting, exercising, and escaping natural enemies are all different brain cells in different brain regions."

No need for a spell, no wand, this optogenetic technique is like installing a light-controlled switch in the brain, using specific light as a control signal to regulate the activity of brain neurons. Just like we use a remote control to control TV and other home appliances.

The discovery of basic research in brain science has great significance for people to deeply understand brain function, develop new clinical treatment technologies for neurological diseases and new targets for drugs; and, it provides new targets for the treatment of cerebral ischemia and tumors. Point; precise intervention in epilepsy and Parkinson's disease is also achieved in animal models. The research has applied for more than 160 invention patents, and has been authorized more than 100 pieces. It has already radiated about 400 laboratories inside and outside China. Relevant academic papers have been published in international science and technology authoritative journals such as Nature Communications, which has produced a wide range of academic influences. (Nanfang Daily reporter Lin Yazhen)

Source: Nanfang Daily

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